Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.998


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB6chr17_-_466823330.638.5e-03Click!
HOXA7chr7_-_271961630.381.5e-01Click!
HOXB7chr17_-_466879250.292.7e-01Click!
HOXA6chr7_-_271873670.224.2e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_14086901 28.732 NFIB
nuclear factor I/B
chr3_+_159557745 16.163 SCHIP1
schwannomin interacting protein 1
chr2_+_102508377 15.917 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr3_+_159557649 14.235 NM_001197109
 SCHIP1
schwannomin interacting protein 1
chr3_+_158787040 13.762 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
 IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr2_+_102508333 13.412 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chrX_+_135251795 11.140 NM_001167819
 FHL1
four and a half LIM domains 1
chr5_+_71502700 10.326 MAP1B
microtubule-associated protein 1B
chr7_-_27205123 10.033 HOXA9
homeobox A9
chr2_-_216259197 9.972 FN1
fibronectin 1
chr2_-_216241321 9.722 FN1
fibronectin 1
chr7_-_27205148 9.185 NM_152739
 HOXA9
homeobox A9
chr9_+_97521930 9.144 NM_001193329
 C9orf3
chromosome 9 open reading frame 3
chrX_+_135278912 9.104 NM_001159701
NM_001159699
 FHL1

four and a half LIM domains 1

chr10_-_126716452 8.992 NM_022802
 CTBP2
C-terminal binding protein 2
chrX_+_135251454 8.702 NM_001159704
 FHL1
four and a half LIM domains 1
chr12_-_91576805 8.369 NM_001920
 DCN
decorin
chr7_-_41742666 8.337 NM_002192
 INHBA
inhibin, beta A
chr13_-_38172862 7.938 NM_001135934
NM_001135935
NM_001135936
NM_006475
 POSTN



periostin, osteoblast specific factor



chr22_-_36236330 7.920 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 74 entries
Enrichment   P-value GO Accession GO Term
41.43 2.85e-02 GO:0016199 axon midline choice point recognition
19.50 4.29e-04 GO:0008038 neuron recognition
9.61 1.84e-03 GO:0008037 cell recognition
9.41 2.18e-03 GO:0048704 embryonic skeletal system morphogenesis
9.21 3.04e-05 GO:0048706 embryonic skeletal system development
9.04 6.90e-04 GO:0007519 skeletal muscle tissue development
8.73 9.46e-04 GO:0060538 skeletal muscle organ development
7.62 1.12e-02 GO:0051147 regulation of muscle cell differentiation
6.10 1.09e-06 GO:0007517 muscle organ development
5.74 4.16e-03 GO:0014706 striated muscle tissue development
5.72 1.54e-03 GO:0060537 muscle tissue development
5.63 5.00e-03 GO:0048705 skeletal system morphogenesis
5.53 8.14e-04 GO:0009952 anterior/posterior pattern formation
5.31 3.41e-03 GO:0048562 embryonic organ morphogenesis
5.26 2.50e-07 GO:0061061 muscle structure development
5.20 1.09e-02 GO:0007156 homophilic cell adhesion
5.03 6.03e-03 GO:0043062 extracellular structure organization
4.63 1.11e-03 GO:0003002 regionalization
4.24 7.12e-05 GO:0001501 skeletal system development
4.05 1.36e-03 GO:0001568 blood vessel development

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
6.20 2.94e-04 GO:0044420 extracellular matrix part
5.85 5.31e-04 GO:0030016 myofibril
5.48 1.01e-03 GO:0043292 contractile fiber
5.47 2.74e-03 GO:0044449 contractile fiber part
5.19 1.95e-08 GO:0005578 proteinaceous extracellular matrix
5.14 3.09e-02 GO:0030017 sarcomere
4.30 8.09e-07 GO:0031012 extracellular matrix
4.19 2.73e-02 GO:0005912 adherens junction
4.14 1.42e-02 GO:0070161 anchoring junction
3.20 1.46e-02 GO:0015629 actin cytoskeleton
2.56 1.49e-02 GO:0030054 cell junction
2.38 2.03e-04 GO:0044421 extracellular region part
2.16 3.50e-02 GO:0005615 extracellular space
1.79 1.31e-02 GO:0005576 extracellular region
1.56 1.01e-03 GO:0071944 cell periphery
1.55 2.05e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
3.67 4.54e-04 GO:0003779 actin binding
2.90 8.80e-05 GO:0005509 calcium ion binding
2.88 1.02e-04 GO:0043565 sequence-specific DNA binding
2.50 3.45e-02 GO:0008092 cytoskeletal protein binding
2.45 2.34e-04 GO:0001071 nucleic acid binding transcription factor activity
2.45 2.34e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
2.12 1.70e-02 GO:0030528 transcription regulator activity